BDBM138351 US8877944, 101
SMILES NC(=O)c1ccc(F)c2CN(C3CCN(CC3)C3CCC(F)(F)CC3)C(=O)c12
InChI Key InChIKey=MSLJBNUZYHPJBH-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 138351
Affinity DataIC50: 1.90E+3nM Kd: 80nMAssay Description:The assay is based on the use of a probe of formula (IP) that binds to the NAD binding pocket and takes advantage of the significant change in the po...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataKd: 80nMAssay Description:Binding affinity to full length recombinant human PARP-1 by fluorescence polarization displacement assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of PARP1 in human HeLa cells assessed as reduction of H2O2-induced PAR formation preincubated for 30 mins followed by H2O2 addition measur...More data for this Ligand-Target Pair