BDBM139465 US8889672, 317-080-001
SMILES CCOC(=O)c1c(N)scc1-c1ccc(cc1)N(C)C
InChI Key InChIKey=YAZWNGDLKIJVLM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 139465
Affinity DataIC50: 1.00E+3nMAssay Description:IC50 values were determined using an in vitro luminescence-based kinase assay against aPKCζ to elucidate a pharmacophore. The IC50 values determ...More data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Inhibition of atypical PKCzeta (unknown origin) using CREBtide as substrate incubated for 1 hr measured every 2.5 mins by ADP Quest assayMore data for this Ligand-Target Pair
TargetProtein kinase C iota type(Homo sapiens (Human))
Penn State University College Of Medicine
Curated by ChEMBL
Penn State University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:Inhibition of atypical PKCiota (unknown origin) using CREBtide as substrate incubated for 1 hr measured every 2.5 mins by ADP Quest assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Penn State University College Of Medicine
Curated by ChEMBL
Penn State University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Inhibition of atypical PKCzeta in HEK293 cells assessed as TNF-induced NFkappaB activation incubated for 3 hrs prior to TNF induction measured after ...More data for this Ligand-Target Pair