BDBM14029 (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE::4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-1-carboxamide::US10183931, Y-27632::Y-27632

SMILES C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1

InChI Key InChIKey=IYOZTVGMEWJPKR-UHFFFAOYSA-N

Data  20 KI  39 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 59 hits for monomerid = 14029   

TargetRho-associated protein kinase 2(Human)
Banasthali Vidyapith

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of ROCK2 (unknown origin) assessed as phosphorylation of MYPT1 using Tetramethylbenzidine as substrate in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataKi:  25.1nMAssay Description:Inhibition of ROCK-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataKi:  40nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 46nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Banasthali Vidyapith

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 54nMAssay Description:Inhibition of ROCK2 (unknown origin) using long S6 kinase peptide as substrate by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Banasthali Vidyapith

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 54nMAssay Description:Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Banasthali Vidyapith

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataKi:  60nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Banasthali Vidyapith

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 61nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 70nMAssay Description:Inhibition of Prkcl2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Banasthali Vidyapith

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 89nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 93nMAssay Description:Inhibition of ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Banasthali Vidyapith

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataKi:  140nMAssay Description:Inhibition of ROCK2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataKi:  140nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataKi:  140nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Banasthali Vidyapith

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 143nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataKi:  150nM ΔG°:  -9.46kcal/molepH: 7.6 T: 2°CAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2007
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataKi:  150nMAssay Description:Inhibition of human leukocytic ROCK1 expressed in insect cells using KKRNRTLSV as substrate after 10 mins by pyruvate kinase/lactate dehydrogenase co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataKi:  150nMAssay Description:Inhibition of human ROCK1 by homogenous luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 150nMAssay Description:Inhibition of human recombinant N-terminal his-tagged ROCK1 (3-543) expressed in baculovirus infected Sf9 cells using Biotin-Ahx-AKRRLSSLRA-CONH2 sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataKi:  220nMAssay Description:Binding affinity to ROCK1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataKi:  220nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataKi:  220nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Banasthali Vidyapith

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 245nMAssay Description:Inhibition of ROCK-2 by Immobilized metal ion affinity-based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Banasthali Vidyapith

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 260nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Banasthali Vidyapith

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataKi:  300nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Banasthali Vidyapith

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataKi:  300nMAssay Description:Inhibition of human ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Banasthali Vidyapith

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataKi:  300nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Banasthali Vidyapith

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataKi:  300nMAssay Description:Inhibition of human ROCK2 by homogenous luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Banasthali Vidyapith

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataKi:  300nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Banasthali Vidyapith

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataKi:  300nMAssay Description:Binding affinity to ROCK2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetProtein kinase C epsilon type(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 335nMAssay Description:Inhibition of PrkceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Bovine)
German Cancer Research Center

LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 500nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2007
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 600nMAssay Description:Inhibition of Protein kinase C related kinase 2 (PRK2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 600nMAssay Description:Inhibition of His-tagged human PRK2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Banasthali Vidyapith

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 700nMAssay Description:Inhibition of Protein kinase ROCK2 (ROCKII)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Rat)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 800nMAssay Description:Inhibition of rat ROCK2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 871nMAssay Description:Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 1.13E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of N terminal histidine tagged human recombinant ROCK1 (3 to 543 residues) expressed in baculovirus infected Sf9 cells using biotin-Ahx-AK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Banasthali Vidyapith

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 1.63E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetC-C motif chemokine 2(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 2.63E+3nMAssay Description:Inhibition of MCP1-mediated human THP cell migrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataKi: >5.00E+3nM ΔG°: >-7.35kcal/molepH: 7.6 T: 2°CAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2007
Entry Details Article
PubMed
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 6.00E+3nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2007
Entry Details Article
PubMed
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 6.00E+3nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2007
Entry Details Article
PubMed
TargetCell division control protein 42 homolog(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of CDc42More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetMyotonin-protein kinase(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of DMPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of His-tagged human MSK1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 9.00E+3nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2007
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha [T183A](Bovine)
German Cancer Research Center

LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 9.00E+3nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2007
Entry Details Article
PubMed
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 1.20E+4nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2007
Entry Details Article
PubMed
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