BDBM14157 APC-10605::CHEMBL64097::N-(4-carbamimidoylphenyl)-2-hydroxy-3-iodo-5-methylbenzamide

SMILES Cc1cc(I)c(O)c(c1)C(=O)Nc1ccc(cc1)C(N)=N

InChI Key InChIKey=JECHDKUWRBFZLB-UHFFFAOYSA-N

Data  11 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 14157   

TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM14157(APC-10605 | CHEMBL64097 | N-(4-carbamimidoylphenyl...)
Affinity DataKi:  80nMAssay Description:Inhibition of urokinase-type plasminogen activator (microPa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14157(APC-10605 | CHEMBL64097 | N-(4-carbamimidoylphenyl...)
Affinity DataKi:  190nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14157(APC-10605 | CHEMBL64097 | N-(4-carbamimidoylphenyl...)
Affinity DataKi:  240nMAssay Description:Activation of plasminogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM14157(APC-10605 | CHEMBL64097 | N-(4-carbamimidoylphenyl...)
Affinity DataKi:  290nMAssay Description:Inhibition of plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM14157(APC-10605 | CHEMBL64097 | N-(4-carbamimidoylphenyl...)
Affinity DataKi:  330nM ΔG°:  -8.75kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM14157(APC-10605 | CHEMBL64097 | N-(4-carbamimidoylphenyl...)
Affinity DataKi:  380nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM14157(APC-10605 | CHEMBL64097 | N-(4-carbamimidoylphenyl...)
Affinity DataKi:  460nMAssay Description:Inhibition of coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM14157(APC-10605 | CHEMBL64097 | N-(4-carbamimidoylphenyl...)
Affinity DataKi:  530nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Axys Pharmaceutical

LigandPNGBDBM14157(APC-10605 | CHEMBL64097 | N-(4-carbamimidoylphenyl...)
Affinity DataKi:  610nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM14157(APC-10605 | CHEMBL64097 | N-(4-carbamimidoylphenyl...)
Affinity DataKi:  2.20E+3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM14157(APC-10605 | CHEMBL64097 | N-(4-carbamimidoylphenyl...)
Affinity DataKi:  3.20E+3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed