BDBM14158 APC-11922::CHEMBL293260::N-(4-carbamimidoyl-3-fluorophenyl)-2-hydroxy-3-iodo-5-methylbenzamide

SMILES Cc1cc(I)c(O)c(c1)C(=O)Nc1ccc(C(N)=N)c(F)c1

InChI Key InChIKey=GDPHNLIBJUAUNC-UHFFFAOYSA-N

Data  11 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 14158   

TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM14158(APC-11922 | CHEMBL293260 | N-(4-carbamimidoyl-3-fl...)
Affinity DataKi:  270nMAssay Description:Inhibition of urokinase-type plasminogen activator (microPa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM14158(APC-11922 | CHEMBL293260 | N-(4-carbamimidoyl-3-fl...)
Affinity DataKi:  270nM ΔG°:  -8.86kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14158(APC-11922 | CHEMBL293260 | N-(4-carbamimidoyl-3-fl...)
Affinity DataKi:  410nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14158(APC-11922 | CHEMBL293260 | N-(4-carbamimidoyl-3-fl...)
Affinity DataKi:  410nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14158(APC-11922 | CHEMBL293260 | N-(4-carbamimidoyl-3-fl...)
Affinity DataKi:  500nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14158(APC-11922 | CHEMBL293260 | N-(4-carbamimidoyl-3-fl...)
Affinity DataKi:  520nMAssay Description:Inhibition of coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14158(APC-11922 | CHEMBL293260 | N-(4-carbamimidoyl-3-fl...)
Affinity DataKi:  1.40E+3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14158(APC-11922 | CHEMBL293260 | N-(4-carbamimidoyl-3-fl...)
Affinity DataKi:  1.70E+3nMAssay Description:Activation of plasminogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Axys Pharmaceutical

LigandPNGBDBM14158(APC-11922 | CHEMBL293260 | N-(4-carbamimidoyl-3-fl...)
Affinity DataKi:  2.80E+3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM14158(APC-11922 | CHEMBL293260 | N-(4-carbamimidoyl-3-fl...)
Affinity DataKi:  5.50E+3nMAssay Description:Inhibition of plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM14158(APC-11922 | CHEMBL293260 | N-(4-carbamimidoyl-3-fl...)
Affinity DataKi:  5.50E+3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed