BDBM14320 1-amino-isoquinoline::CHEMBL62083::Fragment 17::fragment 1 (J. med. chem.,50,1116)::isoquinolin-1-amine
SMILES Nc1nccc2ccccc12
InChI Key InChIKey=OSILBMSORKFRTB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 14320
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataKi: 5.01E+4nMAssay Description:Inhibition of urokinaseMore data for this Ligand-Target Pair
Affinity DataKi: 3.90E+5nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
Affinity DataKi: 5.94E+5nMAssay Description:Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...More data for this Ligand-Target Pair
Affinity DataKi: 6.00E+5nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Bristol-Myers Squibb R & D
Curated by ChEMBL
Bristol-Myers Squibb R & D
Curated by ChEMBL
Affinity DataKi: 4.00E+6nMAssay Description:Inhibition of recombinant human factor-7a/TF using S2288 as substrate measured after 60 minsMore data for this Ligand-Target Pair
Affinity DataKd: 6.87E+5nMAssay Description:Binding affinity to immobilized recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cel...More data for this Ligand-Target Pair
Affinity DataKd: 6.50E+5nMAssay Description:Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarizationMore data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibitory activity against endothelial nitric oxide synthase (eNOS)More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibitory activity against neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+6nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
Affinity DatapH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibitory activity against inducible nitric oxide synthase (iNOS)More data for this Ligand-Target Pair