BDBM143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25

SMILES Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1

InChI Key InChIKey=DIVFYQCMVDWPOD-UHFFFAOYSA-N

Data  66 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 143761   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM143761(US10183953, Example 25 | US8969352, 22 | US8969352...)
Affinity DataKi:  15nMAssay Description:Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM143761(US10183953, Example 25 | US8969352, 22 | US8969352...)
Affinity DataKi:  16nMAssay Description:Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
TBA

US Patent
LigandPNGBDBM143761(US10183953, Example 25 | US8969352, 22 | US8969352...)
Affinity DataKi:  17nMAssay Description:Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
TBA

US Patent
LigandPNGBDBM143761(US10183953, Example 25 | US8969352, 22 | US8969352...)
Affinity DataKi:  20nMAssay Description:Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM143761(US10183953, Example 25 | US8969352, 22 | US8969352...)
Affinity DataKi:  23nMAssay Description:Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
TBA

US Patent
LigandPNGBDBM143761(US10183953, Example 25 | US8969352, 22 | US8969352...)
Affinity DataKi:  25nMAssay Description:Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin receptor type 2(Rattus norvegicus (Rat))
TBA

US Patent
LigandPNGBDBM143761(US10183953, Example 25 | US8969352, 22 | US8969352...)
Affinity DataKi:  466nMAssay Description:Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin receptor type 2(Rattus norvegicus (Rat))
TBA

US Patent
LigandPNGBDBM143761(US10183953, Example 25 | US8969352, 22 | US8969352...)
Affinity DataKi:  692nMAssay Description:Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin receptor type 2(Rattus norvegicus (Rat))
TBA

US Patent
LigandPNGBDBM143761(US10183953, Example 25 | US8969352, 22 | US8969352...)
Affinity DataKi:  1.00E+3nMAssay Description:Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin receptor type 2(Rattus norvegicus (Rat))
TBA

US Patent
LigandPNGBDBM143761(US10183953, Example 25 | US8969352, 22 | US8969352...)
Affinity DataKi: >1.00E+4nMAssay Description:Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
TBA

US Patent
LigandPNGBDBM143761(US10183953, Example 25 | US8969352, 22 | US8969352...)
Affinity DataKi: >1.00E+4nMAssay Description:Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...More data for this Ligand-Target Pair
In DepthDetails US Patent