BDBM144315 Gilteritinib::US11512074, Example T-9::US8969336, 547::US8969336, 577

SMILES CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(CC3)N3CCN(C)CC3)c(OC)c2)nc1NC1CCOCC1

InChI Key InChIKey=GYQYAJJFPNQOOW-UHFFFAOYSA-N

Data  5 KI  37 IC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 144315   

TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Astellas Pharma

US Patent
LigandPNGBDBM144315(Gilteritinib | US11512074, Example T-9 | US8969336...)
Affinity DataIC50:  0.410nMAssay Description:A partial protein of only a kinase domain of FLT3 protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Examp...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Astellas Pharma

US Patent
LigandPNGBDBM144315(Gilteritinib | US11512074, Example T-9 | US8969336...)
Affinity DataIC50:  1.90nMAssay Description:A partial protein of only a kinase domain of ROS protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Exampl...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor(Homo sapiens (Human))
Astellas Pharma

US Patent
LigandPNGBDBM144315(Gilteritinib | US11512074, Example T-9 | US8969336...)
Affinity DataIC50:  1.5nMAssay Description:A recombinant retrovirus was created from expression plasmid FLAG-EML4-ALKv1/pMX-iresCD8 in which cDNA for EMLA-ALK fusion protein v1 was integrated,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Astellas Pharma

US Patent
LigandPNGBDBM144315(Gilteritinib | US11512074, Example T-9 | US8969336...)
Affinity DataIC50:  3.40nMAssay Description:A partial protein of only a kinase domain of RET protein was purchased from Carna Biosciences Inc., Japan. The phosphorylation activity toward a pept...More data for this Ligand-Target Pair
In DepthDetails US Patent