BDBM14712 (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide::A77 1726::CHEMBL973::CHEMBL999::TERIFLUNOMIDE

SMILES CC(=O)C(C#N)C(=O)Nc1ccc(cc1)C(F)(F)F

InChI Key InChIKey=NABQBYDEMLGCEO-UHFFFAOYSA-N

Data  5 KI  19 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 14712   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM14712((2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)pheny...)
Affinity DataIC50:  420nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
LigandPNGBDBM14712((2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)pheny...)
Affinity DataIC50:  156nMAssay Description:Inhibitory activity against mouse dihydroorotate dehydrogenaseMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
4Sc

Curated by ChEMBL
LigandPNGBDBM14712((2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)pheny...)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity against rat dihydroorotate dehydrogenaseMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM14712((2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)pheny...)
Affinity DataIC50:  435nMAssay Description:In vitro inhibitory activity against human dihydroorotate dehydrogenase (DHODH)More data for this Ligand-Target Pair