BDBM152692 Thiol-SAHA (t-SAHA)
SMILES SCCCCCCC(=O)Nc1ccccc1
InChI Key InChIKey=CFKBMXXDXYFDET-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 152692
Affinity DataIC50: 210nMAssay Description:In vitro inhibitory activity against human histone deacetylase (HDAC) using HeLa nuclear extractMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
R&D Sigma-Tau Industrie Farmaceutiche Riunite
Curated by ChEMBL
R&D Sigma-Tau Industrie Farmaceutiche Riunite
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of HDAC6 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
R&D Sigma-Tau Industrie Farmaceutiche Riunite
Curated by ChEMBL
R&D Sigma-Tau Industrie Farmaceutiche Riunite
Curated by ChEMBL
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of HDAC8 (unknown origin) using fluorogenic tetrapeptide RHK(Ac)K(Ac) substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
R&D Sigma-Tau Industrie Farmaceutiche Riunite
Curated by ChEMBL
R&D Sigma-Tau Industrie Farmaceutiche Riunite
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
R&D Sigma-Tau Industrie Farmaceutiche Riunite
Curated by ChEMBL
R&D Sigma-Tau Industrie Farmaceutiche Riunite
Curated by ChEMBL
Affinity DataIC50: 288nMAssay Description:Inhibition of HDAC1 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Inhibitory concentration against human histone deacetylaseMore data for this Ligand-Target Pair
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
R&D Sigma-Tau Industrie Farmaceutiche Riunite
Curated by ChEMBL
R&D Sigma-Tau Industrie Farmaceutiche Riunite
Curated by ChEMBL
Affinity DataIC50: 270nMAssay Description:Inhibition of HDAC10 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 11(Homo sapiens (Human))
R&D Sigma-Tau Industrie Farmaceutiche Riunite
Curated by ChEMBL
R&D Sigma-Tau Industrie Farmaceutiche Riunite
Curated by ChEMBL
Affinity DataIC50: 262nMAssay Description:Inhibition of HDAC11 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
R&D Sigma-Tau Industrie Farmaceutiche Riunite
Curated by ChEMBL
R&D Sigma-Tau Industrie Farmaceutiche Riunite
Curated by ChEMBL
Affinity DataIC50: 218nMAssay Description:Inhibition of recombinant human HDAC1 using Boc-Lys(Ac)-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using Boc-Lys(Ac)-AMC as substrate preincubated for 15 mins followed by substrate addition meas...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
R&D Sigma-Tau Industrie Farmaceutiche Riunite
Curated by ChEMBL
R&D Sigma-Tau Industrie Farmaceutiche Riunite
Curated by ChEMBL
Affinity DataIC50: 74nMAssay Description:Inhibition of recombinant human HDAC6 using Boc-Lys(Ac)-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
R&D Sigma-Tau Industrie Farmaceutiche Riunite
Curated by ChEMBL
R&D Sigma-Tau Industrie Farmaceutiche Riunite
Curated by ChEMBL
Affinity DataIC50: 201nMAssay Description:Inhibition of HDAC3 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assayMore data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 1 hit for monomerid = 152692
ITC DataΔG°: -7.40kcal/mole −TΔS°: -0.251kcal/mole ΔH°: -4.51kcal/mole logk: 4.17E+5
pH: 7.5 T: -248.15°C
pH: 7.5 T: -248.15°C