BDBM152719 N-(3-{[(2R)-3-amino-2-{[3-(thiophene-2-imidamido)phenyl]methoxy}propoxy]methyl}phenyl)thiophene-2-carboximidamide (23)::US9242957, QJ-II-183

SMILES NC[C@H](COCc1cccc(NC(=N)c2cccs2)c1)OCc1cccc(NC(=N)c2cccs2)c1

InChI Key InChIKey=KEUPBLDQGUHFOB-HSZRJFAPSA-N

Data  6 KI  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 152719   

TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM152719(N-(3-{[(2R)-3-amino-2-{[3-(thiophene-2-imidamido)p...)
Affinity DataKi:  59nMAssay Description:Inhibition of rat nNOS using L-arginine substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM152719(N-(3-{[(2R)-3-amino-2-{[3-(thiophene-2-imidamido)p...)
Affinity DataKi:  59nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

US Patent
LigandPNGBDBM152719(N-(3-{[(2R)-3-amino-2-{[3-(thiophene-2-imidamido)p...)
Affinity DataKi:  8.11E+3nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

US Patent
LigandPNGBDBM152719(N-(3-{[(2R)-3-amino-2-{[3-(thiophene-2-imidamido)p...)
Affinity DataKi:  8.11E+3nMAssay Description:Inhibition of mouse macrophage iNOS using L-arginine substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM152719(N-(3-{[(2R)-3-amino-2-{[3-(thiophene-2-imidamido)p...)
Affinity DataKi:  1.24E+4nMAssay Description:Inhibition of bovine eNOS using L-arginine substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM152719(N-(3-{[(2R)-3-amino-2-{[3-(thiophene-2-imidamido)p...)
Affinity DataKi:  1.24E+4nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase oxygenase(Bacillus subtilis (Firmicutes))
University of California Irvine

LigandPNGBDBM152719(N-(3-{[(2R)-3-amino-2-{[3-(thiophene-2-imidamido)p...)
Affinity DataKd:  1.69E+5nMAssay Description:In short, the difference between the imidazole-bound low-spin peak at 430 nm and the inhibitorbound high-spin peak at 395 nm was measured as a functi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed