BDBM152722 N-{3-[(pyrrolidin-3-yloxy)methyl]phenyl}thiophene-2-carboximidamide (27)::US9242957, 9

SMILES N=C(Nc1cccc(COC2CCNC2)c1)c1cccs1

InChI Key InChIKey=OOJUYDKIKUNGMC-UHFFFAOYSA-N

Data  3 KI  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 152722   

TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM152722(N-{3-[(pyrrolidin-3-yloxy)methyl]phenyl}thiophene-...)
Affinity DataKi:  139nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

US Patent
LigandPNGBDBM152722(N-{3-[(pyrrolidin-3-yloxy)methyl]phenyl}thiophene-...)
Affinity DataKi:  1.58E+4nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

US Patent
LigandPNGBDBM152722(N-{3-[(pyrrolidin-3-yloxy)methyl]phenyl}thiophene-...)
Affinity DataKi:  3.65E+4nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase oxygenase(Bacillus subtilis (Firmicutes))
University of California Irvine

LigandPNGBDBM152722(N-{3-[(pyrrolidin-3-yloxy)methyl]phenyl}thiophene-...)
Affinity DataKd:  7.24E+4nMAssay Description:In short, the difference between the imidazole-bound low-spin peak at 430 nm and the inhibitorbound high-spin peak at 395 nm was measured as a functi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed