BDBM15298 N-{4-[(4R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl]phenyl}acetamide::dihydropyridazinone 6a

SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC(C)=O)cc1

InChI Key InChIKey=GDZXNMWZXLDEKG-MRVPVSSYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 15298   

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [387-1112](Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15298(N-{4-[(4R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyrida...)
Affinity DataIC50:  37nMpH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM15298(N-{4-[(4R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyrida...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant PDE3BMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM15298(N-{4-[(4R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyrida...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human N-terminal His-GST-tagged recombinant PDE3A (669-end residues) using fluorescent labelled cAMP as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A [388-1112](Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15298(N-{4-[(4R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyrida...)
Affinity DataIC50:  96nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed