BDBM153318 BPH-1417
SMILES C1CN=C(N1)c1ccc2cc(\C=C\c3cc4ccc(cc4[nH]3)C3=NCCN3)[nH]c2c1
InChI Key InChIKey=IOVATJAOKLNFKP-AATRIKPKSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 153318
TargetDecaprenyl diphosphate synthase(Mycobacterium tuberculosis H37Rv)
University of California San Diego
University of California San Diego
Affinity DataIC50: 490nMpH: 7.5Assay Description:We screened an in-house library of 43 compounds using GPP as substrate. Briefly, the condensation of IPP and GPP, FPP, or cis-FPP catalyzed by DPPS w...More data for this Ligand-Target Pair
TargetDecaprenyl diphosphate synthase(Mycobacterium tuberculosis H37Rv)
University of California San Diego
University of California San Diego
Affinity DataIC50: 2.00E+4nMpH: 7.5Assay Description:We screened an in-house library of 19 compounds using cis-FPP as substrate. Briefly, the condensation of IPP and GPP, FPP, or cis-FPP catalyzed by DP...More data for this Ligand-Target Pair
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of recombinant human His-tagged PRMT1 expressed in Escherichia coli BL21 (DE3) using biotin-labeled histone H4-20 as substrate incubated f...More data for this Ligand-Target Pair
TargetShort-chain Z-isoprenyl diphosphate synthase(Mycobacterium tuberculosis H37Rv)
University of California San Diego
University of California San Diego
Affinity DataIC50: 4.80E+3nMAssay Description:The IC50 values for the most active hits were verified by radiometric assay as follows. A mixture of 15 µM cis-FPP, 100 nM DPPS, and inhibitors in th...More data for this Ligand-Target Pair
TargetTuberculosinyl adenosine transferase(Mycobacterium tuberculosis H37Rv)
University of California San Diego
University of California San Diego
Affinity DataIC50: 660nMAssay Description:For inhibition assay of Rv3378c, using tuberculosinyl diphosphate and adenosine as substrates, a mixture of 100 µM TPP, 100 µM adenosine,75 µg/mL Rv3...More data for this Ligand-Target Pair