BDBM15343 2-({2,6-difluoro-4-[3-(trifluoromethoxy)phenyl]phenyl}carbamoyl)cyclopent-1-ene-1-carboxylic acid::CHEMBL157105::Compound 4

SMILES OC(=O)C1=C(CCC1)C(=O)Nc1c(F)cc(cc1F)-c1cccc(OC(F)(F)F)c1

InChI Key InChIKey=VTGXLCZUWFYELR-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 15343   

LigandPNGBDBM15343(2-({2,6-difluoro-4-[3-(trifluoromethoxy)phenyl]phe...)
Affinity DataIC50:  33nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
LigandPNGBDBM15343(2-({2,6-difluoro-4-[3-(trifluoromethoxy)phenyl]phe...)
Affinity DataIC50:  33nMAssay Description:In vitro inhibitory activity against human dihydroorotate dehydrogenase (DHODH)More data for this Ligand-Target Pair
LigandPNGBDBM15343(2-({2,6-difluoro-4-[3-(trifluoromethoxy)phenyl]phe...)
Affinity DataIC50:  33nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
4Sc

Curated by ChEMBL
LigandPNGBDBM15343(2-({2,6-difluoro-4-[3-(trifluoromethoxy)phenyl]phe...)
Affinity DataIC50:  504nMAssay Description:Inhibitory activity against rat dihydroorotate dehydrogenaseMore data for this Ligand-Target Pair
LigandPNGBDBM15343(2-({2,6-difluoro-4-[3-(trifluoromethoxy)phenyl]phe...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory activity against mouse dihydroorotate dehydrogenaseMore data for this Ligand-Target Pair