Reaction Details
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Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM15343
Substrate
n/a
Meas. Tech.
ChEMBL_321227 (CHEMBL881227)
IC50
2000±n/a nM
Citation
Leban, J; Kralik, M; Mies, J; Gassen, M; Tentschert, K; Baumgartner, R SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors. Bioorg Med Chem Lett 15:4854-7 (2005) [PubMed] Article More Info.:
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
Dhodh | Dihydroorotate dehydrogenase | PYRD_MOUSE
Type:
PROTEIN
Mol. Mass.:
42711.08
Organism:
Mus musculus
Description:
ChEMBL_1366444
Residue:
395
Sequence:
MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR
Inhibitor
Name:
BDBM15343
Synonyms:
2-({2,6-difluoro-4-[3-(trifluoromethoxy)phenyl]phenyl}carbamoyl)cyclopent-1-ene-1-carboxylic acid | CHEMBL157105 | Compound 4
Type:
Small organic molecule
Emp. Form.:
C20H14F5NO4
Mol. Mass.:
427.3215
SMILES:
OC(=O)C1=C(CCC1)C(=O)Nc1c(F)cc(cc1F)-c1cccc(OC(F)(F)F)c1 |t:3|
Structure:
