BDBM154576 K03861 (1)
SMILES CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ccnc(N)n4)cc3)cc2C(F)(F)F)CC1
InChI Key InChIKey=PWDLXPJQFNVTNL-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 154576
Affinity DataKd: 50nMpH: 7.5 T: 2°CAssay Description:All ITC experiments were performed using a VP-ITC (Microcal, Northampton, MA) instrument at 10 or 15 °C in 50 mM HEPES, pH 7.5, 300 mM NaCl, and 1 mM...More data for this Ligand-Target Pair
Affinity DataKd: 15.4nMpH: 7.5 T: 2°CAssay Description:All ITC experiments were performed using a VP-ITC (Microcal, Northampton, MA) instrument at 10 or 15 °C in 50 mM HEPES, pH 7.5, 300 mM NaCl, and 1 mM...More data for this Ligand-Target Pair
Affinity DataKd: 9.70nMpH: 7.5 T: 2°CAssay Description:All ITC experiments were performed using a VP-ITC (Microcal, Northampton, MA) instrument at 10 or 15 °C in 50 mM HEPES, pH 7.5, 300 mM NaCl, and 1 mM...More data for this Ligand-Target Pair
Affinity DataKd: 53nMAssay Description:Binding affinity to wild-type CDK2 (unknown origin) expressed in baculovirus infected Sf9 insect cells by isothermal titration calorimetric methodMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital Of Zhengzhou University
Curated by ChEMBL
Affinity DataKd: 53nMAssay Description:Binding affinity to CDK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 18.6nMpH: 7.5 T: 2°CAssay Description:All ITC experiments were performed using a VP-ITC (Microcal, Northampton, MA) instrument at 10 or 15 °C in 50 mM HEPES, pH 7.5, 300 mM NaCl, and 1 mM...More data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 4 hits for monomerid = 154576
ITC DataΔG°: -9.55kcal/mole −TΔS°: 5.23kcal/mole ΔH°: -14.8kcal/mole logk: 1.78E+7
pH: 7.5 T: 15.00°C
pH: 7.5 T: 15.00°C
CellCyclin-dependent protein kinase 2 variant (CDK2 C118L)(Homo sapiens (Human))
University of Oxford
University of Oxford
ITC DataΔG°: -10.2kcal/mole −TΔS°: 4.75kcal/mole ΔH°: -14.9kcal/mole logk: 5.51E+7
pH: 7.5 T: 15.00°C
pH: 7.5 T: 15.00°C
CellCyclin-dependent protein kinase 2 variant (CDK2 A144C)(Homo sapiens (Human))
University of Oxford
University of Oxford
ITC DataΔG°: -10.3kcal/mole −TΔS°: 5.51kcal/mole ΔH°: -15.8kcal/mole logk: 6.51E+7
pH: 7.5 T: 15.00°C
pH: 7.5 T: 15.00°C
CellCyclin-dependent protein kinase 2 variant (CDK2 C118L/A144C)(Homo sapiens (Human))
University of Oxford
University of Oxford
ITC DataΔG°: -10.6kcal/mole −TΔS°: 7.57kcal/mole ΔH°: -18.2kcal/mole logk: 1.12E+8
pH: 7.5 T: 15.00°C
pH: 7.5 T: 15.00°C