BDBM15458 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]-2-methoxypyrimidine::4-[4-(4-fluorophenyl)-1-piperidin-4-yl-1H-imidazol-5-yl]-2-methoxypyrimidine::CHEMBL95692::SB-242235::SB242235
SMILES COc1nccc(n1)-c1c(ncn1C1CCNCC1)-c1ccc(F)cc1
InChI Key InChIKey=PDTYLGXVBIWRIM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 15458
Affinity DataIC50: 83nMAssay Description:Inhibition of PKCalpha kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: >50nMAssay Description:Inhibition of JNK1 kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: >20nMAssay Description:Inhibition of JNK 2 beta2 kinaseMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: >50nMAssay Description:Inhibition of ERK2 kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
Affinity DataIC50: >100nMAssay Description:Inhibition of cdc2 kinaseMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: >50nMAssay Description:Inhibition of cRaf kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: >10nMAssay Description:Inhibition of EGFR kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: >10nMAssay Description:Inhibition of p56 Lck kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of PKC-beta2 kinaseMore data for this Ligand-Target Pair