BDBM15754 (2S)-3-(3-{[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]carbonyl}phenoxy)propane-1,2-diol::5-Amino-1-(4-fluorophenyl)-4-[3-{2(S), 3-dihydroxypropoxy}benzoyl]pyrazole::CHEMBL203567::RO3201195::aminopyrazole 63

SMILES Nc1c(cnn1-c1ccc(F)cc1)C(=O)c1cccc(OC[C@@H](O)CO)c1

InChI Key InChIKey=IJDQETGUEUJVTB-HNNXBMFYSA-N

Data  5 IC50  1 Kd

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 15754   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

LigandPNGBDBM15754((2S)-3-(3-{[5-amino-1-(4-fluorophenyl)-1H-pyrazol-...)
Affinity DataIC50:  700nMAssay Description:Inhibition of human recombinant active p38alpha MAP kinase was tested by measuring the incorporation of 33P from gamma-[33P] ATP into myelin basic pr...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM15754((2S)-3-(3-{[5-amino-1-(4-fluorophenyl)-1H-pyrazol-...)
Affinity DataKd:  5.00E+3nMAssay Description:Inhibition of JNK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

LigandPNGBDBM15754((2S)-3-(3-{[5-amino-1-(4-fluorophenyl)-1H-pyrazol-...)
Affinity DataIC50:  180nMAssay Description:Inhibition of p38alpha in hTERT-immortalized human HCA2 cells assessed as decrease in phosphorylated HSP27 level by ELISA in presence of anisomycinMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

LigandPNGBDBM15754((2S)-3-(3-{[5-amino-1-(4-fluorophenyl)-1H-pyrazol-...)
Affinity DataIC50:  500nMAssay Description:Inhibition of p38alpha (unknown origin)-mediated TNFalpha production in peripheral mononucleocytesMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

LigandPNGBDBM15754((2S)-3-(3-{[5-amino-1-(4-fluorophenyl)-1H-pyrazol-...)
Affinity DataIC50:  400nMAssay Description:Inhibition of p38alpha (unknown origin)-mediated IL1beta production in peripheral mononucleocytesMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

LigandPNGBDBM15754((2S)-3-(3-{[5-amino-1-(4-fluorophenyl)-1H-pyrazol-...)
Affinity DataIC50:  250nMAssay Description:Inhibition of p38alpha-induced TNFalpha production in human THP1 cellsMore data for this Ligand-Target Pair