BDBM160509 US10280160, Example 1.::US9682969, 1

SMILES CN(C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccccc2c1=O)c1ccc2nc(C)oc2c1

InChI Key InChIKey=RMNQRSAGJVUIBD-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 160509   

TargetCystic fibrosis transmembrane conductance regulator [1-507,509-1480](Homo sapiens (Human))
Flatley Discovery Lab

US Patent
LigandPNGBDBM160509(US10280160, Example 1. | US9682969, 1)
Affinity DataEC50: <1.00E+4nMAssay Description:This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Y. B. Chavan College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM160509(US10280160, Example 1. | US9682969, 1)
Affinity DataEC50: <1.00E+4nMAssay Description:Inhibition of human CFTR F508 deletion mutant expressed in rat FRT cells coexpressing YFP-H148Q/I152L 25,22 incubated for 60 to 120 mins in presence ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Y. B. Chavan College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM160509(US10280160, Example 1. | US9682969, 1)
Affinity DataEC50: <1.00E+4nMAssay Description:Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent