BDBM163243 US9062045, Comparator No. 1 (JNJ-38877605)
SMILES Cn1cc(cn1)-c1ccc2nnc(n2n1)C(F)(F)c1ccc2ncccc2c1
InChI Key InChIKey=JRWCBEOAFGHNNU-UHFFFAOYSA-N
Data 10 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 163243
Affinity DataIC50: 3nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of C-Met (unknown origin) using polu (Glu,Tyr)4:1 substrate after 30 mins incubation by multi-well spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Inhibition of c-Met in human EBC-1 cells assessed as reduction in cell proliferation after 72 hrs by SRB or MTT assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor/Nucleoprotein TPR(Mus musculus)
Chinese Academy Of Sciences (Cas)
Curated by ChEMBL
Chinese Academy Of Sciences (Cas)
Curated by ChEMBL
Affinity DataIC50: 8.60nMAssay Description:Inhibition of TPR-MET in mouse BAF3 cells assessed as reduction in cell proliferation after 72 hrs by SRB or MTT assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.950nMAssay Description:Inhibition of recombinant c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 9.5nMAssay Description:Inhibition of c-Met in human MKN45 cells assessed as reduction in cell proliferation after 72 hrs by SRB or MTT assayMore data for this Ligand-Target Pair