BDBM163243 US9062045, Comparator No. 1 (JNJ-38877605)

SMILES Cn1cc(cn1)-c1ccc2nnc(n2n1)C(F)(F)c1ccc2ncccc2c1

InChI Key InChIKey=JRWCBEOAFGHNNU-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 163243   

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163243(US9062045, Comparator No. 1 (JNJ-38877605))
Affinity DataIC50:  3nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163243(US9062045, Comparator No. 1 (JNJ-38877605))
Affinity DataIC50:  4.00E+3nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163243(US9062045, Comparator No. 1 (JNJ-38877605))
Affinity DataIC50:  1nMAssay Description:Inhibition of C-Met (unknown origin) using polu (Glu,Tyr)4:1 substrate after 30 mins incubation by multi-well spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163243(US9062045, Comparator No. 1 (JNJ-38877605))
Affinity DataIC50:  4nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163243(US9062045, Comparator No. 1 (JNJ-38877605))
Affinity DataIC50:  2.60nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163243(US9062045, Comparator No. 1 (JNJ-38877605))
Affinity DataIC50:  5.5nMAssay Description:Inhibition of c-Met in human EBC-1 cells assessed as reduction in cell proliferation after 72 hrs by SRB or MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor/Nucleoprotein TPR(Mus musculus)
Chinese Academy Of Sciences (Cas)

Curated by ChEMBL
LigandPNGBDBM163243(US9062045, Comparator No. 1 (JNJ-38877605))
Affinity DataIC50:  8.60nMAssay Description:Inhibition of TPR-MET in mouse BAF3 cells assessed as reduction in cell proliferation after 72 hrs by SRB or MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163243(US9062045, Comparator No. 1 (JNJ-38877605))
Affinity DataIC50:  0.950nMAssay Description:Inhibition of recombinant c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163243(US9062045, Comparator No. 1 (JNJ-38877605))
Affinity DataIC50:  1.70nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163243(US9062045, Comparator No. 1 (JNJ-38877605))
Affinity DataIC50:  9.5nMAssay Description:Inhibition of c-Met in human MKN45 cells assessed as reduction in cell proliferation after 72 hrs by SRB or MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed