BDBM165355 US8168651, Compound TABLE 16.22::US9062043, Table 13, Compound 22::US9062043, Table 20b, Compound 15

SMILES OC(=O)c1ccc2c(c1)nc(Nc1cccc(c1)C#C)c1ncncc21

InChI Key InChIKey=HJGFPNFAFSFDNN-UHFFFAOYSA-N

Data  1 KI  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 165355   

TargetCasein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM165355(US8168651, Compound TABLE 16.22 | US9062043, Table...)
Affinity DataKi:  420nMAssay Description:Inhibition of CK2alpha (unknown origin) using RRRADDSDDDDD as substrate in presence of [gamma33P]-ATP by autoradiographyMore data for this Ligand-Target Pair
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM165355(US8168651, Compound TABLE 16.22 | US9062043, Table...)
Affinity DataIC50:  6nMAssay Description:Test compounds in aqueous solution were added at a volume of 10 microliters, to a reaction mixture comprising 10 microliters Assay Dilution Buffer (A...More data for this Ligand-Target Pair
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM165355(US8168651, Compound TABLE 16.22 | US9062043, Table...)
Affinity DataIC50:  6nMpH: 7.2Assay Description:Test compounds in aqueous solution were added at a volume of 10 microliters, to a reaction mixture comprising 10 microliters Assay Dilution Buffer (A...More data for this Ligand-Target Pair
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM165355(US8168651, Compound TABLE 16.22 | US9062043, Table...)
Affinity DataIC50:  98nMpH: 7.4Assay Description:The human leukemia Jurkat T-cell line was maintained in RPMI 1640 (Cambrex) supplemented with 10% fetal calf serum and 50 ng/ml Geutamycin. Before tr...More data for this Ligand-Target Pair