BDBM173255 US10323032, Example 7::US9096596, 7::US9604982, Example 7
SMILES Clc1cccc(C(=O)N2CCc3c(C2)ncnc3-c2ccn[nH]2)c1Cl
InChI Key InChIKey=NTUQVIQEPHGASW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 173255
Affinity DataKi: 15nMAssay Description:Displacement of [3H]A-804598 from human recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells after 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Therachem Research Medilab (India)
Curated by ChEMBL
Therachem Research Medilab (India)
Curated by ChEMBL
Affinity DataKi: 15nMAssay Description:Displacement of [3H]A-804598 from rat recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells after 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 562nMAssay Description:Antagonist activity against ATP-gated P2X7 receptor in LPS-stimulated human whole blood assessed as reduction in P2X7 agonist 2'(3')-O-(4-benzoylbenz...More data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Therachem Research Medilab (India)
Curated by ChEMBL
Therachem Research Medilab (India)
Curated by ChEMBL
Affinity DataIC50: 489nMAssay Description:Antagonist activity against rat recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells assessed as reduction in BzATP -induced Ca2+ flux...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Antagonist activity against human recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells assessed as reduction in BzATP -induced Ca2+ fl...More data for this Ligand-Target Pair