BDBM173828 US9102591, (+)2-chloro-N-[2-(4-fluorophenyl)-2-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl]benzamide::US9102591, (-)2-chloro-N-[2-(4-fluorophenyl)-2-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl]benzamide::US9649308, (-)2-chloro-N-[2-(4-fluorophenyl)-2-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl]benzamide

SMILES Fc1ccc(cc1)C(CNC(=O)c1ccccc1Cl)c1cnc(nc1)C(F)(F)F

InChI Key InChIKey=QLQIKVJKFWIZSN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 173828   

TargetP2X purinoceptor 7(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM173828(US9102591, (+)2-chloro-N-[2-(4-fluorophenyl)-2-[2-...)
Affinity DataIC50:  4.40nMpH: 7.4 T: 2°CAssay Description:Fluorescent Imaging Plate Reader (FLIPR) assay: Briefly, 293-human or mouse P2X7 stable cells were incubated in sucrose buffer, pH 7.4 [KCl (5 mM), N...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM173828(US9102591, (+)2-chloro-N-[2-(4-fluorophenyl)-2-[2-...)
Affinity DataIC50:  2nMAssay Description:Fluorescent Imaging Plate Reader (FLIPR) assay: Briefly, 293-human or mouse P2X7 stable cells were incubated in sucrose buffer, pH 7.4 [KCl (5 mM), N...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM173828(US9102591, (+)2-chloro-N-[2-(4-fluorophenyl)-2-[2-...)
Affinity DataIC50:  4.40nMAssay Description:Fluorescent Imaging Plate Reader (FLIPR) assay: Briefly, 293-human or mouse P2X7 stable cells were incubated in sucrose buffer, pH 7.4 [KCl (5 mM), N...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM173828(US9102591, (+)2-chloro-N-[2-(4-fluorophenyl)-2-[2-...)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Fluorescent Imaging Plate Reader (FLIPR) assay: Briefly, 293-human or mouse P2X7 stable cells were incubated in sucrose buffer, pH 7.4 [KCl (5 mM), N...More data for this Ligand-Target Pair
In DepthDetails US Patent