BDBM174796 US10053462, 27::US9102686, 27::US9540388, 27

SMILES COc1ccnc(c1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F

InChI Key InChIKey=SDWUWEKAOFIYDK-PXAZEXFGSA-N

Data  2 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 174796   

TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174796(US10053462, 27 | US9102686, 27 | US9540388, 27)
Affinity DataKi:  4nM IC50:  1.91E+3nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174796(US10053462, 27 | US9102686, 27 | US9540388, 27)
Affinity DataKi:  4nM IC50:  1.54E+3nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2X purinoceptor 7(Mus musculus)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174796(US10053462, 27 | US9102686, 27 | US9540388, 27)
Affinity DataIC50:  1.54E+3nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174796(US10053462, 27 | US9102686, 27 | US9540388, 27)
Affinity DataIC50:  1.54E+3nMpH: 7.4Assay Description:Ca.sup.2+flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Me...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174796(US10053462, 27 | US9102686, 27 | US9540388, 27)
Affinity DataIC50:  1.91E+3nMpH: 7.4Assay Description:Ca.sup.2+flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Me...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174796(US10053462, 27 | US9102686, 27 | US9540388, 27)
Affinity DataIC50:  1.91E+3nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In DepthDetails US Patent