BDBM176003 US10047103, 36::US9688695, 36

SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(=O)N(C)C)cc(OC)cc2o1

InChI Key InChIKey=KEEBLYWBELVGPQ-UHFFFAOYSA-N

Data  9 IC50  2 Kd  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 176003   

TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM176003(US10047103, 36 | US9688695, 36)
Affinity DataEC50:  0.450nMT: 2°CAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM176003(US10047103, 36 | US9688695, 36)
Affinity DataEC50: >1.50E+4nMAssay Description:Agonist activity at PXR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM176003(US10047103, 36 | US9688695, 36)
Affinity DataEC50:  2.10nMT: 2°CAssay Description:Briefly, PRP or washed platelet suspension (100 μl) was pre-incubated for 5 minutes at room temperature with varying concentrations of compounds...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM176003(US10047103, 36 | US9688695, 36)
Affinity DataIC50:  2.10nMT: 2°CAssay Description:The ability of the compounds of the current invention to inhibit platelet aggregation induced by gamma-thrombin was tested in a 96-well microplate ag...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM176003(US10047103, 36 | US9688695, 36)
Affinity DataIC50:  3.40nMAssay Description:Antagonist activity at PAR4 in human platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turbidim...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM176003(US10047103, 36 | US9688695, 36)
Affinity DataIC50:  0.400nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM176003(US10047103, 36 | US9688695, 36)
Affinity DataKd:  0.100nMAssay Description:Binding affinity to PAR4 (unknown origin) assessed as saturation bindingMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM176003(US10047103, 36 | US9688695, 36)
Affinity DataKd:  0.0860nMAssay Description:Binding affinity to PAR4 (unknown origin) assessed as association constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM176003(US10047103, 36 | US9688695, 36)
Affinity DataIC50: >7.00E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM176003(US10047103, 36 | US9688695, 36)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of CYP2C8 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM176003(US10047103, 36 | US9688695, 36)
Affinity DataIC50: >7.00E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM176003(US10047103, 36 | US9688695, 36)
Affinity DataIC50: >7.00E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM176003(US10047103, 36 | US9688695, 36)
Affinity DataIC50: >7.00E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM176003(US10047103, 36 | US9688695, 36)
Affinity DataIC50: >7.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM176003(US10047103, 36 | US9688695, 36)
Affinity DataEC50:  0.450nMT: 2°CAssay Description:Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...More data for this Ligand-Target Pair
In DepthDetails US Patent