BDBM1774 US10894048, Ref. Ex Comp. 1::US8476284, 13

SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@H]1CCCN(C1)C(=O)C=C

InChI Key InChIKey=XYFPWWZEPKGCCK-SFHVURJKSA-N

Data  19 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 1774   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM1774(US10894048, Ref. Ex Comp. 1 | US8476284, 13)
Affinity DataIC50: <0.5nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM1774(US10894048, Ref. Ex Comp. 1 | US8476284, 13)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant human GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus expression system incubated for 1 hr by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Shaanxi University Of Science & Technology

Curated by ChEMBL
LigandPNGBDBM1774(US10894048, Ref. Ex Comp. 1 | US8476284, 13)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of SYK (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Shaanxi University Of Science & Technology

Curated by ChEMBL
LigandPNGBDBM1774(US10894048, Ref. Ex Comp. 1 | US8476284, 13)
Affinity DataIC50:  78nMAssay Description:Inhibition of TEC (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Shaanxi University Of Science & Technology

Curated by ChEMBL
LigandPNGBDBM1774(US10894048, Ref. Ex Comp. 1 | US8476284, 13)
Affinity DataIC50:  11nMAssay Description:Inhibition of ITK (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM1774(US10894048, Ref. Ex Comp. 1 | US8476284, 13)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of BTK (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM1774(US10894048, Ref. Ex Comp. 1 | US8476284, 13)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of BTK (unknown origin) after 60 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM1774(US10894048, Ref. Ex Comp. 1 | US8476284, 13)
Affinity DataIC50:  280nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM1774(US10894048, Ref. Ex Comp. 1 | US8476284, 13)
Affinity DataIC50:  19nMAssay Description:Inhibition of human BTK using poly (Glu,Tyr) as substrate in presence of ATP and Ci(gamma33-P) ATP measured by microplate reader assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM1774(US10894048, Ref. Ex Comp. 1 | US8476284, 13)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of full-length N-terminal GST tagged BTK (1 to 659 residues) (unknown origin) expressed in Sf21 insect cells using NH2-ETVYSEVRK-biotin as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM1774(US10894048, Ref. Ex Comp. 1 | US8476284, 13)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of N-terminal DYKDDDD-tagged EGFR (669 to 1210 residues) (unknown origin) expressed in Sf21 insect cells using NH2-ETVYSEVRK-biotin as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM1774(US10894048, Ref. Ex Comp. 1 | US8476284, 13)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of N-terminal GST-tagged BMX (1 to 675 residues) (unknown origin) expressed in Sf21 insect cells using NH2-ETVYSEVRK-biotin as substrate p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Shaanxi University Of Science & Technology

Curated by ChEMBL
LigandPNGBDBM1774(US10894048, Ref. Ex Comp. 1 | US8476284, 13)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of N-terminal GST-tagged ITK (2 to 620 residues) (unknown origin) expressed in Sf21 insect cells using NH2-ETVYSEVRK-biotin as substrate p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM1774(US10894048, Ref. Ex Comp. 1 | US8476284, 13)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant human GST-tagged JAK3 expressed in baculovirus expression system incubated for 1 hr by Z'lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM1774(US10894048, Ref. Ex Comp. 1 | US8476284, 13)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ERBB4 catalytic domain expressed in baculovirus expression system incubated for 1 hr by Z'-LYTE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM1774(US10894048, Ref. Ex Comp. 1 | US8476284, 13)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant human His-tagged LCK expressed in baculovirus expression system incubated for 1 hr by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Shaanxi University Of Science & Technology

Curated by ChEMBL
LigandPNGBDBM1774(US10894048, Ref. Ex Comp. 1 | US8476284, 13)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant human GST-tagged full length ITK expressed in baculovirus expression system incubated for 1 hr by Z'lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM1774(US10894048, Ref. Ex Comp. 1 | US8476284, 13)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant human His-tagged full length BLK expressed in baculovirus expression system incubated for 1 hr by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Shaanxi University Of Science & Technology

Curated by ChEMBL
LigandPNGBDBM1774(US10894048, Ref. Ex Comp. 1 | US8476284, 13)
Affinity DataIC50:  200nMAssay Description:Inhibition of LYN (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed