BDBM18136 ADP, alpha beta-me::AMPCPP::[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)methyl]phosphonic acid::alpha, beta-methyleneadenosine 5 -diphosphate::cid_92199
SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O
InChI Key InChIKey=OLCWZBFDIYXLAA-IOSLPCCCSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 24 hits for monomerid = 18136
Affinity DataKi: 88nMAssay Description:Inhibition of purified recombinant soluble human CD73 expressed in Sf9 cells [3H]AMP as substrate incubated for 25 mins by scintillation counting met...More data for this Ligand-Target Pair
Affinity DataKi: 88nMAssay Description:Inhibition of human CD73 using AMP as substrate by Malachite green phosphate reagent-based assayMore data for this Ligand-Target Pair
Affinity DataKi: 88nMAssay Description:Inhibition of human CD73More data for this Ligand-Target Pair
Affinity DataKi: 88nMAssay Description:Inhibition of human recombinant soluble CD73 assessed as inhibition constant by radiometric assayMore data for this Ligand-Target Pair
Affinity DataKi: 88nMAssay Description:Inhibition of CD73 (unknown origin)More data for this Ligand-Target Pair
Target5'-nucleotidase(Rattus norvegicus (Rat))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 167nMAssay Description:Inhibition of recombinant rat C-terminal His-tagged soluble form of CD73 expressed in baculovirus infected Sf9 insect cells using [2,8-3H]AMP as subs...More data for this Ligand-Target Pair
Target5'-nucleotidase(Rattus norvegicus (Rat))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 197nMAssay Description:Inhibition of purified recombinant soluble rat CD73 expressed in Sf9 cells [3H]AMP as substrate incubated for 25 mins by scintillation counting metho...More data for this Ligand-Target Pair
Affinity DataKi: 207nMAssay Description:Inhibition of native CD73 in human MDA-MB-231 cell membrane preparations [3H]AMP as substrate incubated for 25 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 510nMAssay Description:Inhibition of CD73 in human melanoma 1539 cells using AMP substrate by capillary electrophoresis assayMore data for this Ligand-Target Pair
Target5'-nucleotidase(Rattus norvegicus (Rat))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 870nMAssay Description:Inhibition of rat CD73 expressed in baculovirus infected insect cells using AMP substrate by capillary electrophoresis assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.63E+4nMAssay Description:Inhibition of CD73 in human NCI-H1568 cells assessed as reduction in AMP-induced ADO expression preincubated for 15 mins followed by AMP addition and...More data for this Ligand-Target Pair
Affinity DataIC50: 3.97E+3nMAssay Description:Inhibition of human CD73 assessed as reduction in inorganic phosphate release upon substrate hydrolysis using AMP/ATP as substrate incubated for 1 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 4.63E+3nMAssay Description:Inhibition of mouse CD73 assessed as reduction in inorganic phosphate release upon substrate hydrolysis using AMP/ATP as substrate incubated for 1 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 2.65E+3nMAssay Description:Inhibition of human C-terminal His6-tagged CD73 expressed in CHO cells preincubated for 15 mins followed by AMP addition and measured after 10 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 187nMAssay Description:Inhibition of human CD73 using AMP as substrate by Malachite green phosphate reagent-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.63E+3nMAssay Description:Inhibition of mouse CD73More data for this Ligand-Target Pair
Affinity DataIC50: 3.97E+3nMAssay Description:Inhibition of human CD73More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of human CD73 expressed in CHO cells using AMP as substrate preincubated for 10 mins followed by substrate addition and measured every min...More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of human C-terminal His6-tagged CD73 expressed in HEK293F cells using [15N]5-AMP as substrate preincubated for 1 hr followed by substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant human CD73 using AMP as substrate incubated for 90 mins by malachite green colorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.14E+4nMAssay Description:Inhibition of CD73 in human MDA-MB-231 cells assessed as reduction in conversion of AMP to adenosine incubated for 30 mins by malachite green reagent...More data for this Ligand-Target Pair
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of recombinant CD73 (27 to 549 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells assessed as reduction in conv...More data for this Ligand-Target Pair
Affinity DataIC50: 2.36E+4nMAssay Description:Inhibition of CD73 in human NCI-H292 cells assessed as reduction in conversion of AMP to adenosine incubated for 30 mins by malachite green reagent b...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of recombinant human CD73 using AMP as substrate incubated for 120 mins by CellTiter-Glo assayMore data for this Ligand-Target Pair