BDBM182826 US9145426, 2
SMILES COc1nc(nc(C)c1F)N1C[C@@H]2[C@](C1)(NC(=N)N(C)S2(=O)=O)c1ccc(F)cc1
InChI Key InChIKey=DHRFNWXFLKOLNR-FZKQIMNGSA-N
Data 2 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 182826
Affinity DataKi: 14nM ΔG°: -10.9kcal/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 were determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
Affinity DataKi: 35nM ΔG°: -10.3kcal/molepH: 5.0 T: 2°CAssay Description:A homogeneous time-resolved FRET assay was used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay monit...More data for this Ligand-Target Pair