BDBM18351 (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 10::(2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol::1-Deoxynojirimycin::1-deoxynojirimycin (DNJ)::CHEMBL307429::US20230339856, Compound DNJ::US9181184, 1::dNM

SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O

InChI Key InChIKey=LXBIFEVIBLOUGU-JGWLITMVSA-N

Data  26 KI  104 IC50  1 EC50

PDB links: 9 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 129 hits for monomerid = 18351   

TargetNeutral alpha-glucosidase AB(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  14nMpH: 6.0Assay Description:Competitive Inhibition constant of the compound was determined on rice alpha Glucosidase at pH 8.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  24nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal sucraseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
University Of Toyama

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  59nMAssay Description:Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
University Of Toyama

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  150nMAssay Description:Tested in vitro for the inhibition constant against human lysosomal alpha-glucosidaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutral alpha-glucosidase AB(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  160nMpH: 5.0Assay Description:Competitive Inhibition constant of the compound was determined on yeast alpha Glucosidase at pH 5.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetTrehalose synthase/amylase TreS(Mycobacterium tuberculosis)
University Of British Columbia

LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  250nMAssay Description:The inhibition of TreS by a range of known alpha-glucosidase inhibitor was assayed.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
University Of Toyama

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  3.40E+3nMAssay Description:The inhibiting activity on recombinant human acid α-glucosidase (rhGAA) of the compounds is implemented using the Fluopol-ABPP method (Fluoresce...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-glucosidase(Prunus avium)
TBA

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  9.50E+3nMAssay Description:Inhibitory activity against sweet almond Beta-glucosidaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-glucosidase(Agrobacterium tumefaciens)
Technische UniversitäT Graz

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibition of Agrobacterium sp. beta-glucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-glucosidase(Agrobacterium tumefaciens)
Technische UniversitäT Graz

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibition of Agrobacterium sp. beta glucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
University Of Hamburg

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  1.80E+4nMAssay Description:Compound tested for inhibition of alpha-galactosidase from Aspergillus nigerMore data for this Ligand-Target Pair
TargetAlpha-glucosidase MAL12(Saccharomyces cerevisiae)
Gyeongsang National University

LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  1.80E+4nM IC50:  3.95E+4nMAssay Description:All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutral alpha-glucosidase AB(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  2.10E+4nMpH: 7.0Assay Description:Competitive Inhibition constant of the compound was determined on yeast alpha Glucosidase at pH 7.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutral alpha-glucosidase AB(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  2.30E+4nMpH: 6.0Assay Description:Competitive Inhibition constant of the compound was determined on yeast alpha Glucosidase at pH 6.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
University Of Toyama

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  2.50E+4nMAssay Description:Inhibitory activity against alpha-glucosidase of yeastMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Technische Universit£T Berlin

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  4.70E+4nMAssay Description:Inhibitory activity against beta-glucosidase of sweet almondMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-mannosidase 2(Rattus norvegicus)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi: <5.00E+4nMAssay Description:Competitive Inhibitory activity against Golgi Alpha-mannosidase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Technische Universit£T Berlin

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  7.90E+4nM ΔG°:  -5.82kcal/mole IC50:  2.40E+5nMpH: 5.5 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Technische Universit£T Berlin

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  7.90E+4nMAssay Description:Inhibition of human lysosomal beta-glucocerebrosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-mannosidase(Canavalia ensiformis)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  2.70E+5nMAssay Description:Inhibition of jack bean alpha-mannosidase using p-nitrophenyl-mannopyranoside as substrate measured every 2 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Technische Universit£T Berlin

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  3.00E+5nMpH: 5.0Assay Description:Competitive Inhibition constant of the compound was determined on almonds beta Glucosidase at pH 5.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Technische Universit£T Berlin

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  3.00E+5nMpH: 5.0Assay Description:Competitive Inhibition constant of the compound was determined on yeast alpha Glucosidase at pH 7.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutral alpha-glucosidase AB(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  4.10E+5nMAssay Description:Tested for competitive inhibition of golgi alpha mannosidase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutral alpha-glucosidase AB(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  4.60E+5nMpH: 5.0Assay Description:Competitive Inhibition constant of the compound was determined on rice alpha Glucosidase at pH 5.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-mannosidase(Bacteroides thetaiotaomicron)
The Medical School, Newcastle University

LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  1.40E+7nM ΔG°:  -2.63kcal/molepH: 5.6 T: 2°CAssay Description:Putative mannosidase assay using wild-type protein Btman2A. Enzyme inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue alpha-L-fucosidase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi: >1.00E+8nMAssay Description:Inhibition constant against Alpha-FucosidaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against rat intestinal isomaltase using disaccharideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPutative alpha-glucosidase(Oryza sativa subsp. japonica)
Universit£

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against alpha-Glucosidase from riceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-glucosidase A(Caldocellum saccharolyticum)
Universit£

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  5.50E+4nMAssay Description:Inhibitory activity against beta-Glucosidase from Caldocellum saccharolyticumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  360nMAssay Description:Inhibitory activity against rat intestinal maltase using disaccharideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  210nMAssay Description:Inhibitory activity against rat intestinal sucrase using disaccharideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-glucosidase(Prunus avium)
TBA

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  8.10E+4nMAssay Description:Inhibitory activity against beta-Glucosidase from sweet almondMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaltase-glucoamylase(Homo sapiens (Human))
Toyama Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  40nMAssay Description:Inhibitory concentration against human alpha-glucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosolic beta-glucosidase(Homo sapiens (Human))
Toyama Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  2.40E+5nMAssay Description:Inhibitory concentration against human beta-glucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPutative alpha-glucosidase(Oryza sativa subsp. japonica)
Universit£

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  30nMAssay Description:Inhibitory concentration against rice alpha-glucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  650nMAssay Description:Inhibitory concentration against rat intestinal maltaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
University Of Sydney

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of non-lysosomal glucosylceramidase in cultured melanoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Technische Universit£T Berlin

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  1.18E+5nMAssay Description:Inhibitory activity was determined against Escherichia coli Alpha-galactosidaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAlpha-glucosidase MAL62(Saccharomyces cerevisiae)
University Of Karachi

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  4.26E+8nMAssay Description:Inhibition of yeast alpha-glucosidase using para-nitrophenyl alpha-D-glucopyranoside as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Rattus norvegicus)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  130nMAssay Description:Inhibition of rat intestinal brush border membrane maltaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  160nMAssay Description:Inhibition of rat intestinal brush border membrane isomaltaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  210nMAssay Description:Inhibition of rat intestinal brush border membrane sucraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
University Of Toyama

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human lysosomal alpha-glucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Technische Universit£T Berlin

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  2.40E+5nMAssay Description:Inhibition of human lysosomal beta-glucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen debranching enzyme(Oryctolagus cuniculus)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  190nMAssay Description:Inhibition of rabbit muscle amylo-1,6-glucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
University Of Toyama

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  60nMAssay Description:Inhibition of maltase in human Caco-2 cell model system after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrehalase(Sus scrofa)
University Of Toyama

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  4.10E+4nMAssay Description:Inhibition of porcine kidney trehalaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrehalase(Rattus norvegicus)
University Of Toyama

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  4.20E+4nMAssay Description:Inhibition of rat intestinal trehalaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactase/phlorizin hydrolase(Rattus norvegicus)
University Of Toyama

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of rat intestinal lactase using lactose as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Technische Universit£T Berlin

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  1.95E+5nMAssay Description:Inhibition of human beta-glucocerebrosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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