BDBM185147 (Z)-but-2-enedioic acid;8-(6-methoxypyridin-3-yl)-3-methyl-1-[4-piperazin-1-yl-3-(trifluoromethyl)phenyl]imidazo[4,5-c]quinolin-2-one::BGT-226::US9284315, BGT-226

SMILES COc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(-c4ccc(N5CCNCC5)c(c4)C(F)(F)F)c3c2c1

InChI Key InChIKey=BMMXYEBLEBULND-UHFFFAOYSA-N

Data  8 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 185147   

TargetFerrochelatase, mitochondrial [R115L](Homo sapiens (Human))
Technical University of Munich

LigandPNGBDBM185147((Z)-but-2-enedioic acid;8-(6-methoxypyridin-3-yl)-...)
Affinity DataKd:  3.40E+3nMAssay Description:Briefly, 5 mg of a protein mixture of the four cell lines or a single cell line were incubated with compound dilution series in DMSO (3 nM, 10 nM, 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Zuanzhu Pharma

US Patent
LigandPNGBDBM185147((Z)-but-2-enedioic acid;8-(6-methoxypyridin-3-yl)-...)
Affinity DataIC50:  41.9nMpH: 7.5 T: 2°CAssay Description:1. Preparation of test reagents{circle around (1)} 1x kinase buffer (50 mM HEPES, pH 7.5, 3 mM MgCl2, 1 mM EGTA, 100 mM NaCl, 0.03% CHAPS, 2 mM DTT);...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Zuanzhu Pharma

US Patent
LigandPNGBDBM185147((Z)-but-2-enedioic acid;8-(6-methoxypyridin-3-yl)-...)
Affinity DataIC50:  1.99nMpH: 7.5 T: 2°CAssay Description:1. Preparation of test reagents {circle around (1)} 1x kinase buffer (50 mM HEPES, pH 7.5, 10 mM MgCl2, 1 mM EGTA, 3 mM MnCl, 0.01% Tween-20, 2 mM DT...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Zuanzhu Pharma

US Patent
LigandPNGBDBM185147((Z)-but-2-enedioic acid;8-(6-methoxypyridin-3-yl)-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bioland Laboratory (Guangzhou Regenerative Medicine And Health - Guangdong Laboratory)

Curated by ChEMBL
LigandPNGBDBM185147((Z)-but-2-enedioic acid;8-(6-methoxypyridin-3-yl)-...)
Affinity DataIC50:  38nMAssay Description:Inhibition of PI3Kdelta (unknown origin) expressed in baculovirus expression system using L-alpha-phosphatidylinositol as substrate by luminescence a...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM185147((Z)-but-2-enedioic acid;8-(6-methoxypyridin-3-yl)-...)
Affinity DataIC50:  38nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Zuanzhu Pharma

US Patent
LigandPNGBDBM185147((Z)-but-2-enedioic acid;8-(6-methoxypyridin-3-yl)-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kalpha (unknown origin) expressed in baculovirus expression system using L-alpha-phosphatidylinositol as substrate by luminescence a...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Bioland Laboratory (Guangzhou Regenerative Medicine And Health - Guangdong Laboratory)

Curated by ChEMBL
LigandPNGBDBM185147((Z)-but-2-enedioic acid;8-(6-methoxypyridin-3-yl)-...)
Affinity DataIC50:  63nMAssay Description:Inhibition of PI3Kbeta (unknown origin) expressed in baculovirus expression system using L-alpha-phosphatidylinositol as substrate by luminescence as...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Bioland Laboratory (Guangzhou Regenerative Medicine And Health - Guangdong Laboratory)

Curated by ChEMBL
LigandPNGBDBM185147((Z)-but-2-enedioic acid;8-(6-methoxypyridin-3-yl)-...)
Affinity DataIC50:  63nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed