BDBM18886 3-{3,5-dibromo-4-[4-hydroxy-3-(propan-2-yl)-5-[(E)-2-(pyridin-4-yl)ethenyl]phenoxy]phenyl}propanoic acid::JMC496635 Compound 6::thyromimetic, 6

SMILES CC(C)c1cc(Oc2c(Br)cc(CCC(O)=O)cc2Br)cc(\C=C\c2ccncc2)c1O

InChI Key InChIKey=JFQSWHAFVANRQE-HWKANZROSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 18886   

TargetThyroid hormone receptor beta(Homo sapiens (Human))
Karo Bio

LigandPNGBDBM18886(3-{3,5-dibromo-4-[4-hydroxy-3-(propan-2-yl)-5-[(E)...)
Affinity DataIC50:  22nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Karo Bio

LigandPNGBDBM18886(3-{3,5-dibromo-4-[4-hydroxy-3-(propan-2-yl)-5-[(E)...)
Affinity DataIC50:  22nM EC50:  32nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta. EC50 is the concentration of compound required to i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Karo Bio

LigandPNGBDBM18886(3-{3,5-dibromo-4-[4-hydroxy-3-(propan-2-yl)-5-[(E)...)
Affinity DataIC50:  36nM EC50:  32nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. EC50 is the concentration of compound required to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Karo Bio

LigandPNGBDBM18886(3-{3,5-dibromo-4-[4-hydroxy-3-(propan-2-yl)-5-[(E)...)
Affinity DataIC50:  36nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed