BDBM18916 2-{4-[3-bromo-4-(2-methylbutanamido)phenoxy]-3,5-dichlorophenyl}acetic acid::4-amido bioisosteric ligand, 12c

SMILES CCC(C)C(=O)Nc1ccc(Oc2c(Cl)cc(CC(O)=O)cc2Cl)cc1Br

InChI Key InChIKey=MXHYBOCRTUHWOD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 18916   

TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Karo Bio

LigandPNGBDBM18916(2-{4-[3-bromo-4-(2-methylbutanamido)phenoxy]-3,5-d...)
Affinity DataIC50:  240nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
University Of Insubria

Curated by ChEMBL
LigandPNGBDBM18916(2-{4-[3-bromo-4-(2-methylbutanamido)phenoxy]-3,5-d...)
Affinity DataIC50:  4.27nMAssay Description:Inhibition of human thyroid hormone receptor beta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
University Of Insubria

Curated by ChEMBL
LigandPNGBDBM18916(2-{4-[3-bromo-4-(2-methylbutanamido)phenoxy]-3,5-d...)
Affinity DataIC50:  4.30nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed