BDBM189857 US9670196, 1.2 (1S,4R or 1R,4S)-4-(5-(3-((6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl)amino)-5-methylphenyl)thiazol-2-yl)-4-hydroxy-2,2-dimethylcyclohexanecarboxylic acid

SMILES Cc1cc(Nc2ncc3CCCc3n2)cc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(O)=O)C(C)(C)C1

InChI Key InChIKey=YBYJNSLOQXBOAY-NIYFSFCBSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 189857   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM189857(US9670196, 1.2 (1S,4R or 1R,4S)-4-(5-(3-((6,7-dihy...)
Affinity DataIC50:  17.0nMpH: 7.5 T: 2°CAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent