BDBM189867 US9670196, 2.3 (R or S)-5-hydroxy-5-{5-[3- methyl-5- ([1,2,4]triazolo[1,5- a]pyridin-2- ylamino)phenyl]-1,3- thiazol-2-yl}-5,6,7,8- tetrahydronaphthalene-2- carboxylic acid

SMILES Cc1cc(Nc2nc3ccccn3n2)cc(c1)-c1cnc(s1)[C@@]1(O)CCCc2cc(ccc12)C(O)=O

InChI Key InChIKey=BAVFCYKYVATCIC-HHHXNRCGSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 189867   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM189867(US9670196, 2.3 (R or S)-5-hydroxy-5-{5-[3- methyl-...)
Affinity DataIC50:  0.129nMpH: 7.5 T: 2°CAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent