BDBM191640 US9186318, 9

SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCC(=O)NO

InChI Key InChIKey=LYXOBSREVZDKST-UHFFFAOYSA-N

Data  20 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 191640   

TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: >630nMAssay Description:This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 11(Homo sapiens (Human))
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50:  31nMAssay Description:This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50:  12nMAssay Description:This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50:  115nMAssay Description:This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50:  119nMAssay Description:This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50:  172nMAssay Description:This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50:  154nMAssay Description:This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: >630nMAssay Description:This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 2(Homo sapiens (Human))
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50:  431nMAssay Description:The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 3(Homo sapiens (Human))
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 5(Homo sapiens (Human))
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50:  242nMAssay Description:The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 7(Homo sapiens (Human))
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50:  8.94E+3nMAssay Description:The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 9(Homo sapiens (Human))
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50:  19nMAssay Description:This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...More data for this Ligand-Target Pair
In DepthDetails US Patent