BDBM19187 (2S)-2-[({4-[(3-fluorophenyl)methoxy]phenyl}methyl)amino]propanamide::CHEMBL396778::SAG::Safinamide::US9051240, (S)-(+)-2-[4-(3-Fluorobenzyloxy)-benzylamino]-propanamide

SMILES [H][C@@](C)(NCc1ccc(OCc2cccc(F)c2)cc1)C(N)=O

InChI Key InChIKey=NEMGRZFTLSKBAP-LBPRGKRZSA-N

Data  6 KI  67 IC50  1 Kd  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 19187   

TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM19187((2S)-2-[({4-[(3-fluorophenyl)methoxy]phenyl}methyl...)
Affinity DataKi:  5.40nMAssay Description:Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins b...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM19187((2S)-2-[({4-[(3-fluorophenyl)methoxy]phenyl}methyl...)
Affinity DataKi:  17nMAssay Description:Inhibition of human recombinant microsomal MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 min...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM19187((2S)-2-[({4-[(3-fluorophenyl)methoxy]phenyl}methyl...)
Affinity DataEC50:  1.50E+4nMAssay Description:Inhibition of human recombinant soluble MAO-B assessed as thermal shift after 20 mins by SYPRO orange staining-based fluorescence assayMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM19187((2S)-2-[({4-[(3-fluorophenyl)methoxy]phenyl}methyl...)
Affinity DataKd:  187nMAssay Description:Binding affinity to human recombinant microsomal MAO-B by ITCMore data for this Ligand-Target Pair