BDBM194495 US9200020, Table 3 compound 4

SMILES OP(O)(=O)CCN(CCn1c[nH]c2c1nc[nH]c2=O)CC#N

InChI Key InChIKey=JOZQFWHAFKGCKZ-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 194495   

TargetHypoxanthine-guanine phosphoribosyltransferase(Homo sapiens (Human))
The University of Queensland

US Patent
LigandPNGBDBM194495(US9200020, Table 3 compound 4)
Affinity DataKi:  3.50E+4nM ΔG°:  -6.32kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxanthine phosphoribosyltransferase(Plasmodium vivax)
The University of Queensland

US Patent
LigandPNGBDBM194495(US9200020, Table 3 compound 4)
Affinity DataKi:  4.70E+4nM ΔG°:  -6.14kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
The University of Queensland

US Patent
LigandPNGBDBM194495(US9200020, Table 3 compound 4)
Affinity DataKi: >2.50E+5nM ΔG°: >-5.11kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent