BDBM19731 2-Cyano-pyrimidine, 16a::2-cyano-4-(cyclohexylamino)-N-(2-phenylethyl)pyrimidine-5-carboxamide::CHEMBL386506

SMILES O=C(NCCc1ccccc1)c1cnc(nc1NC1CCCCC1)C#N

InChI Key InChIKey=UEZMKFGTDYYCKL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 19731   

TargetCathepsin K(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM19731(2-Cyano-pyrimidine, 16a | 2-cyano-4-(cyclohexylami...)
Affinity DataIC50:  0.0100nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM19731(2-Cyano-pyrimidine, 16a | 2-cyano-4-(cyclohexylami...)
Affinity DataIC50:  1.10nMpH: 5.5 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM19731(2-Cyano-pyrimidine, 16a | 2-cyano-4-(cyclohexylami...)
Affinity DataIC50:  130nMAssay Description:Inhibition of human recombinant cathepsin S by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM19731(2-Cyano-pyrimidine, 16a | 2-cyano-4-(cyclohexylami...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human recombinant cathepsin L by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM19731(2-Cyano-pyrimidine, 16a | 2-cyano-4-(cyclohexylami...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant cathepsin K by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM19731(2-Cyano-pyrimidine, 16a | 2-cyano-4-(cyclohexylami...)
Affinity DataIC50:  0.130nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed