BDBM200425 US10011599, Example 52::US9227969, 52

SMILES COCC(=O)N1CC[C@@H]([C@@H](F)C1)n1c(C)nc2cnc3cc(F)c(cc3c12)-c1ccc(Oc2ncccn2)cc1Cl

InChI Key InChIKey=BQYYPCSULGHPTA-OZXSUGGESA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 200425   

LigandPNGBDBM200425(US10011599, Example 52 | US9227969, 52)
Affinity DataIC50:  9nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM200425(US10011599, Example 52 | US9227969, 52)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM200425(US10011599, Example 52 | US9227969, 52)
Affinity DataIC50:  9nMAssay Description:[MEK1 1mM ATP IC50 uM] A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An en...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent