BDBM200461 US10011599, Example 90::US9227969, 90::US9629836, 90
SMILES Cc1nc2cnc3cc(F)c(cc3c2n1[C@H]1CCN(C[C@@H]1F)C(=O)CO)-c1ccc(Oc2ncccn2)cc1C
InChI Key InChIKey=HXDYCEVDYKSUGB-OZXSUGGESA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 200461
TargetDual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/Serine/threonine-protein kinase B-raf(Homo sapiens (Human))
Novartis
US Patent
Novartis
US Patent
Affinity DataIC50: 2.60nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Novartis
US Patent
Novartis
US Patent
Affinity DataIC50: 2.60nMAssay Description:[MEK1 1mM ATP IC50 uM] A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An en...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1 [K97R](Homo sapiens (Human))
Novartis
US Patent
Novartis
US Patent
Affinity DataIC50: 2.60nMAssay Description:The radioactive filter binding assay is standardized using recombinant human activated BRAF (V599E) kinase (Cat No. 14-557) and kinase dead MEK1 (K97...More data for this Ligand-Target Pair