BDBM202743 US10245267, Example 89::US10709712, Example 89::US9242969, 89::US9694016, 1171
SMILES CC(F)(F)c1cc(ccn1)C(=O)Nc1c[nH]c(=O)c(c1)-c1ccnc(c1)N1CCOCC1
InChI Key InChIKey=MHXDDBSOWRGCEL-UHFFFAOYSA-N
Data 20 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 202743
Affinity DataIC50: >2.50E+4nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase [Y340E,Y341E](Homo sapiens (Human))
Novartis
US Patent
Novartis
US Patent
Affinity DataIC50: 7.69E+3nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair