BDBM20681 2-amino-5-[(4-bromophenyl)methyl]-6-methyl-3H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one::Pyrrolo[3,2-d]pyrimidine analogue, 9

SMILES Cc1cc2nc(N)[nH]c(=O)c2n1Cc1ccc(Br)cc1

InChI Key InChIKey=FPMKGRSJBZZZBG-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 20681   

TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM20681(2-amino-5-[(4-bromophenyl)methyl]-6-methyl-3H,4H,5...)
Affinity DataIC50:  7.50E+3nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

LigandPNGBDBM20681(2-amino-5-[(4-bromophenyl)methyl]-6-methyl-3H,4H,5...)
Affinity DataIC50:  1.80E+4nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Duquesne University

LigandPNGBDBM20681(2-amino-5-[(4-bromophenyl)methyl]-6-methyl-3H,4H,5...)
Affinity DataIC50:  1.30E+3nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Duquesne University

LigandPNGBDBM20681(2-amino-5-[(4-bromophenyl)methyl]-6-methyl-3H,4H,5...)
Affinity DataIC50: >3.00E+4nMAssay Description:DHFRs were assayed spectrophotometrically in the reaction buffer solution containing dihydrofolate. The reaction was initiated with an amount of enzy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

LigandPNGBDBM20681(2-amino-5-[(4-bromophenyl)methyl]-6-methyl-3H,4H,5...)
Affinity DataIC50:  270nMAssay Description:DHFRs were assayed spectrophotometrically in the reaction buffer solution containing dihydrofolate. The reaction was initiated with an amount of enzy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

LigandPNGBDBM20681(2-amino-5-[(4-bromophenyl)methyl]-6-methyl-3H,4H,5...)
Affinity DataIC50: >3.50E+4nMAssay Description:DHFRs were assayed spectrophotometrically in the reaction buffer solution containing dihydrofolate. The reaction was initiated with an amount of enzy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed