BDBM209453 US10328074, Example I-5::US11077107, Example I-5::US9266891, I-5

SMILES CNc1nc(cn2c(C)nnc12)-c1nn(C)c(C)c1Oc1ccccc1

InChI Key InChIKey=IJZDKKQZNSYLGO-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 209453   

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209453(US10328074, Example I-5 | US11077107, Example I-5 ...)
Affinity DataIC50:  8nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [42-168](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209453(US10328074, Example I-5 | US11077107, Example I-5 ...)
Affinity DataIC50:  8nMAssay Description:This assay is used to determine whether the compounds inhibit the interaction between the first (BRD4-BD1) or the second (BRD4-BD2) bromodomain of BR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [44-168](Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM209453(US10328074, Example I-5 | US11077107, Example I-5 ...)
Affinity DataIC50:  8nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [44-168](Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM209453(US10328074, Example I-5 | US11077107, Example I-5 ...)
Affinity DataIC50:  18nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM209453(US10328074, Example I-5 | US11077107, Example I-5 ...)
Affinity DataIC50:  8nMAssay Description:Displacement of biotinylated tetra-acetylated histone H4 peptide from GST-tagged BRD4-BD1 (44 to 168 residues) (unknown origin) measured after 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed