BDBM210854 US9290467, 24::US9290467, 25::US9290467, 26

SMILES Ic1cc2C[C@H](NC(=O)c3ccccc3OC\C=C\COc1cc2)C(=O)NC1(CC1)C#N

InChI Key InChIKey=DEDJCEQXHPYCKY-RTLBZRNLSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 210854   

TargetCysteine protease(Trypanosoma brucei rhodesiense)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM210854(US9290467, 24 | US9290467, 25 | US9290467, 26)
Affinity DataKi:  2.5nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-AMC as substrate by fluorimetric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM210854(US9290467, 24 | US9290467, 25 | US9290467, 26)
Affinity DataIC50:  139nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProcathepsin L(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM210854(US9290467, 24 | US9290467, 25 | US9290467, 26)
Affinity DataIC50:  164nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProcathepsin L(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM210854(US9290467, 24 | US9290467, 25 | US9290467, 26)
Affinity DataIC50:  236nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent