BDBM212271 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine:::US10828299, Example Ex.-2::US10342794, Example Ex.-2::US11517570, Example Ex.-2::US9290505, Ex.-2::US9504684, Ex.-2::US9931338, Ex.-2
SMILES Nc1cncc(n1)-c1cn2ccnc2c(Nc2ccc(cc2)N2CCN(CC2)C2COC2)n1
InChI Key InChIKey=XCIGZBVOUQVIPI-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 22 hits for monomerid = 212271
Affinity DataIC50: 80nMpH: 7.0Assay Description:Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...More data for this Ligand-Target Pair
Affinity DataIC50: 13.5nMAssay Description:Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 13.5nMpH: 7.0 T: 2°CAssay Description:Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...More data for this Ligand-Target Pair
Affinity DataIC50: 13.5nMAssay Description:Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...More data for this Ligand-Target Pair
Affinity DataIC50: 13.5nMAssay Description:Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...More data for this Ligand-Target Pair
Affinity DataIC50: 6.20nMAssay Description:Inhibition of SYK (unknown origin) using XL665-labeled peptide as substrate in presence of ATP measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 24nMAssay Description:Inhibition of SYK in human Ramos cells assessed as reduction in antihuman IgM F(ab)2-induced phosphorylation of BLNK at Y96 residue preincubated for ...More data for this Ligand-Target Pair
Affinity DataEC50: 73nMAssay Description:Inhibition of SYK in human whole blood assessed as reduction in anti-FCepsilonR1 mAb-induced basophil activation by measuring decrease in CD63 surfac...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of wild-type human partial length JAK2 JH1 catalytic domain (A829 to G1132 residues) expressed in mammalian expression system by Kinomesca...More data for this Ligand-Target Pair
Affinity DataEC50: 26nMAssay Description:Inhibition of SYK (unknown origin) in B cells assessed as reduction in alpha IgM-stimulated BTK phosphorylation at Y223 residueMore data for this Ligand-Target Pair
Affinity DataEC50: 34nMAssay Description:Inhibition of SYK (unknown origin) in B cells assessed as reduction in alpha IgM-stimulated AKT phosphorylation at S473 residueMore data for this Ligand-Target Pair
Affinity DataEC50: 37nMAssay Description:Inhibition of SYK (unknown origin) in B cells assessed as reduction in alpha IgM-stimulated ERK phosphorylation at T202/Y204 residueMore data for this Ligand-Target Pair
Affinity DataEC50: 51nMAssay Description:Inhibition of SYK (unknown origin) in B cells assessed as reduction in alpha IgM-stimulated MEK phosphorylation at S217/S221 residueMore data for this Ligand-Target Pair
Affinity DataEC50: 112nMAssay Description:Inhibition of SYK (unknown origin) in B cells assessed as reduction in alpha IgM-stimulated B cells activation by measuring reduction in CD69 express...More data for this Ligand-Target Pair
Affinity DataEC50: 164nMAssay Description:Inhibition of SYK (unknown origin) in B cells assessed as reduction in alpha IgM-stimulated B cells activation by measuring reduction in CD86 express...More data for this Ligand-Target Pair
Affinity DataEC50: 108nMAssay Description:Inhibition of SYK-mediated alpha IgM/alpha CD40-stimulated human B lymphocytes proliferation pretreated for 1 hr followed by stimulation with alpha I...More data for this Ligand-Target Pair
Affinity DataEC50: 1.31E+3nMAssay Description:Inhibition of SYK-mediated alpha CD3/alpha CD28-stimulated human T lymphocytes proliferation measured after 90 hrs by EdU incorporation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 180nMAssay Description:Inhibition of SYK (unknown origin) in macrophages assessed as reduction in immune complex-stimulated TNFalpha secretionMore data for this Ligand-Target Pair
Affinity DataEC50: 90nMAssay Description:Inhibition of SYK (unknown origin) in macrophages assessed as reduction in immune complex-stimulated IL-1 beta secretionMore data for this Ligand-Target Pair
Affinity DataEC50: 700nMAssay Description:Inhibition of SYK (unknown origin) in macrophages assessed as reduction in immune complex-stimulated IL-6 secretionMore data for this Ligand-Target Pair
Affinity DataIC50: 13.5nMAssay Description:Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...More data for this Ligand-Target Pair
Affinity DataIC50: 13.5nMpH: 7.0Assay Description:Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...More data for this Ligand-Target Pair