BDBM21281 (11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphthalen-1-ylcarbonyl)-9-oxa-1-azatricyclo[6.3.1.0^{4,12}]dodeca-2,4(12),5,7-tetraene::(2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl)methanone monomethanesulfonat::CHEMBL188::WIN 55,212-2::WIN 55212-2::WIN-55212::WIN55212-2
SMILES Cc1c(C(=O)c2cccc3ccccc23)c2cccc3OC[C@@H](CN4CCOCC4)n1c23
InChI Key InChIKey=HQVHOQAKMCMIIM-HXUWFJFHSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 21281
Affinity DataIC50: 8.90nMAssay Description:Displacement of [3H]CP-55940 human CB2 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 140nMAssay Description:Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Agonist activity at human CB1 in CHO cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Agonist activity at human CB2 in CHO cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Agonist activity at CB1 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+3nMAssay Description:Displacement of [3H]WIN-55212-2 from CB2 receptor in Sprague-Dawley rat spleen membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:Displacement of [3H]SR141716A from CB1 receptor in Sprague-Dawley rat cerebellum membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 15.7nMAssay Description:Agonist activity at human recombinant CB2 receptor expressed in CHO cell membranes assessed as inhibition of forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
Affinity DataIC50: 63nMAssay Description:Binding affinity to human recombinant CB1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Displacement of [3H]-CP55,940 from human CB2 receptor expressed in Sf9 cell membranes by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 59nMAssay Description:Displacement of [3H]-CP55,940 from human CB1 receptor expressed in HEK293S cell membranes by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of human cannabinoid CB1 receptorMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1/2(Rattus norvegicus (Rat))
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 5.60nMAssay Description:Concentration required to displace 50% of 0.5 nM [3H](aminoalkyl)indole binding to cannabinoid receptor in rat cerebellum membranesMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1/2(Rattus norvegicus (Rat))
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 5.56nMAssay Description:Concentration required to displace 50% of 0.5 nM [3H](aminoalkyl)indole binding to cannabinoid receptor in rat cerebellum membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Displacement of [3H]WIN 55212-2 from human CB2 receptor incubated for 120 mins by scintillation counting methodMore data for this Ligand-Target Pair