BDBM215863 US9302989, 59
SMILES COc1ccc2CN(Cc2c1)C(=O)Nc1ccc(cc1)C(=O)NCCC(C)C
InChI Key InChIKey=JQZOFBYIXFWUHB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 215863
Affinity DataKi: 16nMAssay Description:Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...More data for this Ligand-Target Pair
Affinity DataIC50: 22.9nMpH: 7.5Assay Description:Probe 1:The assay was carried out in 18 uL low volume plates (Owens Corning) in reaction buffer (50 mM HEPES (NaOH), pH 7.5, 100 mM NaCl, 10 mM MgCl2...More data for this Ligand-Target Pair
Affinity DataIC50: 15.4nMpH: 7.5Assay Description:Probe 2:The assay was carried out in 18 uL low volume plates (Owens Corning) in reaction buffer (50 mM HEPES (NaOH), pH 7.5, 100 mM NaCl, 10 mM MgCl2...More data for this Ligand-Target Pair