BDBM21902 4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol-4-ylmethyl)amino]-8-methoxyquinoline-3-carbonitrile::Cyanoquinoline, 15

SMILES COc1cc(NCc2cnc[nH]2)cc2c(Nc3ccc(F)c(Cl)c3)c(cnc12)C#N

InChI Key InChIKey=KPQYADFSXWRWHU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 21902   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21902(4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol...)
Affinity DataIC50:  2.08E+3nMAssay Description:EGFR kinase activity was assayed using poly(Glu4-Tyr) as a substrate. The phosphorylation of tyrosine residue was detected by an ELISA. IC50 calculat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21902(4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol...)
Affinity DataIC50:  130nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed