BDBM223103 N-(2-chloro-6-methylphenyl)-2-((6-((1-(ethylsulfonyl)pyrrolidin-3-yl)amino)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide (5j)

SMILES CCS(=O)(=O)N1CCC(C1)Nc1cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1

InChI Key InChIKey=NHCXDULQCCCWLO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 223103   

TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences

LigandPNGBDBM223103(N-(2-chloro-6-methylphenyl)-2-((6-((1-(ethylsulfon...)
Affinity DataIC50:  48.5nMpH: 7.5 T: 2°CAssay Description:The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences

LigandPNGBDBM223103(N-(2-chloro-6-methylphenyl)-2-((6-((1-(ethylsulfon...)
Affinity DataIC50:  1.32nMpH: 7.5 T: 2°CAssay Description:ABL activity assays were performed in 384-well plate using the FRET-based Z'-Lyteassay system and Tyr-2 peptide substrate according to the manufa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences

LigandPNGBDBM223103(N-(2-chloro-6-methylphenyl)-2-((6-((1-(ethylsulfon...)
Affinity DataIC50:  156nMpH: 7.5 T: 2°CAssay Description:The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed